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Article

Impact of novel TRIM5alpha variants, Gly110Arg and G176del, on the anti-HIV-1 activity and the susceptibility to HIV-1 infection.

AIDS (London, England) - 23 Oct 2009

Nakajima Toshiaki, Nakayama Emi E, Kaur Gurvinder, Terunuma Hiroshi, Mimaya Jun-ich, Ohtani Hitoshi, Mehra Narinder, Shioda Tatsuo, Kimura Akinori

Abstract excerpt

OBJECTIVE: TRIM5alpha is one of the factors contributing to intracellular defense mechanisms against HIV-1 infection. We investigated the association of TRIM5alpha sequence variations with the susceptibility to HIV-1 infection in Japanese and Indian. DESIGN: Sequence variations in TRIM5alpha were investigated in HIV-1-infected patients and ethnic-matched controls. Functional alterations caused by rare variants...

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Source

Identifiers

PMID: 19710594
DOI: 10.1097/QAD.0b013e328331567a

Genes

TRIM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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