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Article

Knockouts of SOD1 and GPX1 exert different impacts on murine islet function and pancreatic integrity.

Antioxidants & redox signaling - 1 Feb 2011

Wang Xiaodan, Vatamaniuk Marko Z, Roneker Carol A, Pepper Matthew P, Hu Liangbiao G, Simmons Rebecca A, Lei Xin Gen

Abstract excerpt

Metabolic subtlety and clinical relevance of different forms of reactive oxygen species in diabetes remain unclear. Using single knockout of Cu,Zn-superoxide dismutase (SOD1(-/-)) or Se-glutathione peroxidase-1 (GPX1(-/-)) and their double-knockout (DKO) mouse models, we determined if elevating endogenously-derived superoxide and hydroperoxide exerted distinct impacts and mechanisms on body glucose homeostasis....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20586612
DOI: 10.1089/ars.2010.3302
PMCID: PMC3026657

Genes

SOD1
GPX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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