Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait.

doi:10.2337/diabetes.48.11.2189

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Article

Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait.

Diabetes - 1 Nov 1999

Mathews C E, Leiter E H

Abstract excerpt

ALS/Lt and ALR/Lt are inbred mouse strains selected for susceptibility and resistance to alloxan (AL)-induced diabetes. Within 24-h after AL administration in vivo, ALS/Lt islets were distinguished from ALR/Lt islets by more extensive necrotic changes. Within 7 days post-AL, ALS/Lt mice exhibited hyperglycemia and hypoinsulinemia, whereas ALR/Lt mice maintained normal plasma insulin and glucose levels. We have...

Topics

Alloxan
Animals
Blood Glucose
Body Weight
Crosses, Genetic
Diabetes Mellitus, Experimental
Female
Free Radicals
Genes, Dominant
Genetic Predisposition to Disease
Genotype
Glucose
Immunity, Innate
Insulin
Insulin Secretion
Islets of Langerhans
Male
Mice

Source

Open in PubMed

Identifiers

PMID: 10535453
DOI: 10.2337/diabetes.48.11.2189

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