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Article

Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait.

Diabetes - 1 Nov 1999

Mathews C E, Leiter E H

Abstract excerpt

ALS/Lt and ALR/Lt are inbred mouse strains selected for susceptibility and resistance to alloxan (AL)-induced diabetes. Within 24-h after AL administration in vivo, ALS/Lt islets were distinguished from ALR/Lt islets by more extensive necrotic changes. Within 7 days post-AL, ALS/Lt mice exhibited hyperglycemia and hypoinsulinemia, whereas ALR/Lt mice maintained normal plasma insulin and glucose levels. We have...

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Source

Identifiers

PMID: 10535453
DOI: 10.2337/diabetes.48.11.2189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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