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Article

Pathological Relationship between Intracellular Superoxide Metabolism and p53 Signaling in Mice.

International journal of molecular sciences - 29 Mar 2021

Watanabe Kenji, Shibuya Shuichi, Ozawa Yusuke, Toda Toshihiko, Shimizu Takahiko

Abstract excerpt

Intracellular superoxide dismutases (SODs) maintain tissue homeostasis via superoxide metabolism. We previously reported that intracellular reactive oxygen species (ROS), including superoxide accumulation caused by cytoplasmic SOD (SOD1) or mitochondrial SOD (SOD2) insufficiency, induced p53 activation in cells. SOD1 loss also induced several age-related pathological changes associated with increased oxidative...

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Identifiers

PMID: 33805584
DOI: 10.3390/ijms22073548
PMCID: PMC8037821

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