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Article

Dietary selenium deficiency partially rescues type 2 diabetes-like phenotypes of glutathione peroxidase-1-overexpressing male mice.

The Journal of nutrition - 1 Nov 2012

Yan Xi, Pepper Matthew P, Vatamaniuk Marko Z, Roneker Carol A, Li Li, Lei Xin Gen

Abstract excerpt

This study was conducted to determine whether dietary Se deficiency precluded overproduction of glutathione peroxidase-1 (GPX1) activity in mice overexpressing (OE) this gene and thus rescued their type 2 diabetes-like phenotypes. A total of 20 male OE and wild-type (WT) mice were fed an Se-deficient (<0.02 mg/kg) diet or an Se-supplemented (0.3 mg/kg as sodium selenite) diet from 1 to 5 mo of age. Dietary Se...

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Identifiers

PMID: 23014491
DOI: 10.3945/jn.112.164764
PMCID: PMC3497934

Genes

GPX1

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