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Article

Diabetic eNOS knockout mice develop distinct macro- and microvascular complications.

Laboratory investigation; a journal of technical methods and pathology - 1 May 2008

Mohan Sumathy, Reddick Robert L, Musi Nicolas, Horn Diane A, Yan Bo, Prihoda Thomas J, Natarajan Mohan, Abboud-Werner Sherry L

Abstract excerpt

Functional consequences of impaired endothelial nitric oxide synthase (eNOS) activity causing organ-specific abnormalities on a diabetic setting are not completely understood. In this study, we extensively characterized a diabetic mouse model (lepr(db/db)) in which eNOS expression is genetically disrupted (eNOS-/-). The eNOS-/-/ lepr(db/db) double-knockout (DKO) mice developed obesity, hyperglycemia,...

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Source

Identifiers

PMID: 18391994
DOI: 10.1038/labinvest.2008.23

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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