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Article

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.

The Journal of clinical investigation - 1 Oct 2008

Song Benbo, Scheuner Donalyn, Ron David, Pennathur Subramaniam, Kaufman Randal J

Abstract excerpt

The progression from insulin resistance to type 2 diabetes is caused by the failure of pancreatic beta cells to produce sufficient levels of insulin to meet the metabolic demand. Recent studies indicate that nutrient fluctuations and insulin resistance increase proinsulin synthesis in beta cells beyond the capacity for folding of nascent polypeptides within the endoplasmic reticulum (ER) lumen, thereby disrupting...

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Share to Cell Survival
Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Secreting Cells

Share to Lipid Peroxidation

Share to Oxidation-Reduction

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Share to Transcription Factor CHOP

Source

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Identifiers

PMID: 18776938
DOI: 10.1172/JCI34587
PMCID: PMC2528909

Genes

EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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