Article
Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans.
Oncotarget - 1 Nov 2012
Walsh Kyle M, Amos Christopher I, Wenzlaff Angela S, Gorlov Ivan P, Sison Jennette D, Wu Xifeng, Spitz Margaret R, Hansen Helen M, Lu Emily Y, Wei Chongjuan, Zhang Huifeng, Chen Wei, Lloyd Stacy M, Frazier Marsha L, Bracci Paige M, Seldin Michael F, Wrensch Margaret R, Schwartz Ann G, Wiencke John K
Abstract excerpt
Studies in European and East Asian populations have identified lung cancer susceptibility loci in nicotinic acetylcholine receptor (nAChR) genes on chromosome 15q25.1 which also appear to influence smoking behaviors. We sought to determine if genetic variation in nAChR genes influences lung cancer susceptibly in African-Americans, and evaluated the association of these cancer susceptibility loci with smoking...
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