Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients.

doi:10.1016/j.jhep.2010.03.022

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients.

Journal of hepatology - 1 Sept 2010

Abe Hiromi, Ochi Hidenori, Maekawa Toshiro, Hayes C Nelson, Tsuge Masataka, Miki Daiki, Mitsui Fukiko, Hiraga Nobuhiko, Imamura Michio, Takahashi Shoichi, Ohishi Waka, Arihiro Koji, Kubo Michiaki, Nakamura Yusuke, Chayama Kazuaki

Abstract excerpt

BACKGROUND & AIMS: A common genetic variation at the IL28 locus has been found to affect the response of peg-interferon and ribavirin combination therapy against chronic hepatitis C virus (HCV) infection. An allele associated with a favorable response (rs8099917 T), which is the major allele in the majority of Asian, American, and European populations, has also been found to be associated with spontaneous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to gamma-Glutamyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepacivirus

Share to Hepatitis C, Chronic

Share to Host-Pathogen Interactions

Share to Interferons

Share to Interleukins

Share to Liver

Share to Viral Core Proteins

Source

Open in PubMed

Identifiers

PMID: 20576307
DOI: 10.1016/j.jhep.2010.03.022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients.PMID 20576307Read ↗

Association of interleukin-28B and hepatitis C genotype 1 with a high viral load and response to pegylated interferon plus ribavirin therapy.Semantic proximity Read ↗

Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.Semantic proximity Read ↗

Genetics of IL28B and HCV--response to infection and treatment.Semantic proximity Read ↗

Genotype rs8099917 near the IL28B gene and amino acid substitution at position 70 in the core region of the hepatitis C virus are determinants of serum apolipoprotein B-100 concentration in chronic hepatitis C.Semantic proximity Read ↗

Genetic variation in interleukin-28B predicts SVR in hepatitis C genotype 1 Argentine patients treated with PEG IFN and ribavirin.Semantic proximity Read ↗

Pharmacogenetics of hepatitis CSemantic proximity Read ↗

Impact of IL28B genetic variation on HCV-induced liver fibrosis, inflammation, and steatosis: a meta-analysis.Semantic proximity Read ↗

IL28B and IL10R -1087 polymorphisms are protective for chronic genotype 1 HCV infection and predictors of response to interferon-based therapy in an East-Central European cohort.Semantic proximity Read ↗

IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction.Semantic proximity Read ↗

Impact of IL28 Genotypes and Modeling the Interactions of HCV Core Protein on Treatment of Hepatitis C.Semantic proximity Read ↗

Impact of viral amino acid substitutions and host interleukin-28b polymorphism on replication and susceptibility to interferon of hepatitis C virus.Semantic proximity Read ↗

Hepatitis C virus infection alters lipid metabolism depending on IL28B polymorphism and viral genotype and modulates gene expression in vivo and in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.