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Article

Impact of viral amino acid substitutions and host interleukin-28b polymorphism on replication and susceptibility to interferon of hepatitis C virus.

Hepatology (Baltimore, Md.) - 2 Sept 2011

Hiraga Nobuhiko, Abe Hiromi, Imamura Michio, Tsuge Masataka, Takahashi Shoichi, Hayes C Nelson, Ochi Hidenori, Tateno Chise, Yoshizato Katsutoshi, Nakamura Yusuke, Kamatani Naoyuki, Chayama Kazuaki

Abstract excerpt

UNLABELLED: Amino acid (aa) substitutions of core 70 and 91 and in the NS5A (nonstructural protein 5A) interferon sensitivity determining region (ISDR) as well as genetic polymorphisms in the host interleukin-28B (IL28B) locus affect the outcome of interferon (IFN)-based therapies for patients with chronic hepatitis C. The combination of these factors and the quasispecies nature of the virus complicate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21618576
DOI: 10.1002/hep.24453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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