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Article

hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches.

Development (Cambridge, England) - 1 Aug 2010

Talbot Jared Coffin, Johnson Stephen L, Kimmel Charles B

Abstract excerpt

The ventrally expressed secreted polypeptide endothelin1 (Edn1) patterns the skeleton derived from the first two pharyngeal arches into dorsal, intermediate and ventral domains. Edn1 activates expression of many genes, including hand2 and Dlx genes. We wanted to know how hand2/Dlx genes might generate distinct domain identities. Here, we show that differential expression of hand2 and Dlx genes delineates domain...

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Identifiers

PMID: 20573696
DOI: 10.1242/dev.049700
PMCID: PMC2927700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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