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Article

edn1 and hand2 Interact in early regulation of pharyngeal arch outgrowth during zebrafish development.

PloS one - 1 Jan 2013

Sasaki Mark M, Nichols James T, Kimmel Charles B

Abstract excerpt

Endothelin-1 (Edn1) signaling provides a critical input to development of the embryonic pharygneal arches and their skeletal derivatives, particularly the articulating joints and the ventral skeleton including the lower jaw. Previous work in zebrafish has mostly focused on the role of Edn1 in dorsal-ventral (DV) patterning, but Edn1 signaling must also regulate tissue size, for with severe loss of the pathway the...

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PMID: 23826316
DOI: 10.1371/journal.pone.0067522
PMCID: PMC3691169

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