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Article

Endothelin-1 regulates the dorsoventral branchial arch patterning in mice.

Mechanisms of development - 1 Apr 2004

Ozeki Hidenori, Kurihara Yukiko, Tonami Kazuo, Watatani Sanae, Kurihara Hiroki

Abstract excerpt

Endothelin-1 (ET-1), a 21-amino acid peptide secreted by the epithelium and core mesenchyme in the branchial arches as well as vascular endothelium, is involved in craniofacial and cardiovascular development through endothelin receptor type-A (EdnrA) expressed in the neural crest-derived ectomesenchyme. Here we show that ET-1(-/-) mutant mice exhibit a homeotic-like transformation of the lower jaw to an upper...

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Identifiers

PMID: 15110048
DOI: 10.1016/j.mod.2004.02.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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