Article
Mouse models of neutropenia reveal progenitor-stage-specific defects.
Nature - 1 Jun 2020
Muench David E, Olsson Andre, Ferchen Kyle, Pham Giang, Serafin Rachel A, Chutipongtanate Somchai, Dwivedi Pankaj, Song Baobao, Hay Stuart, Chetal Kashish, Trump-Durbin Lisa R, Mookerjee-Basu Jayati, Zhang Kejian, Yu Jennifer C, Lutzko Carolyn, Myers Kasiani C, Nazor Kristopher L, Greis Kenneth D, Kappes Dietmar J, Way Sing Sing, Salomonis Nathan, Grimes H Leighton
Abstract excerpt
Advances in genetics and sequencing have identified a plethora of disease-associated and disease-causing genetic alterations. To determine causality between genetics and disease, accurate models for molecular dissection are required; however, the rapid expansion of transcriptional populations identified through single-cell analyses presents a major challenge for accurate comparisons between mutant and wild-type...
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