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Article

Genetic variability in CLU and its association with Alzheimer's disease.

PloS one - 3 Mar 2010

Guerreiro Rita J, Beck John, Gibbs J Raphael, Santana Isabel, Rossor Martin N, Schott Jonathan M, Nalls Michael A, Ribeiro Helena, Santiago Beatriz, Fox Nick C, Oliveira Catarina, Collinge John, Mead Simon, Singleton Andrew, Hardy John

Abstract excerpt

BACKGROUND: Recently, two large genome wide association studies in Alzheimer disease (AD) have identified variants in three different genes (CLU, PICALM and CR1) as being associated with the risk of developing AD. The strongest association was reported for an intronic single nucleotide polymorphism (SNP) in CLU. METHODOLOGY/PRINCIPAL FINDINGS: To further characterize this association we have sequenced the coding...

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Source

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Identifiers

PMID: 20209083
DOI: 10.1371/journal.pone.0009510
PMCID: PMC2831070

Genes

CLU
PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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Genetic variability in CLU and its association with Alzheimer's disease.PMID 20209083Read ↗

Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.Semantic proximity Read ↗

Association of CLU and PICALM variants with Alzheimer's disease.Semantic proximity Read ↗

Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk.Semantic proximity Read ↗

Replication of CLU, CR1, and PICALM associations with alzheimer disease.Semantic proximity Read ↗

CLU rs9331888 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Caucasian But Not East Asian Populations.Semantic proximity Read ↗

Single Nucleotide Polymorphism rs11136000 of CLU Gene (Clusterin, ApoJ) and the Risk of Late-Onset Alzheimer's Disease in a Central European Population.Semantic proximity Read ↗

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.Semantic proximity Read ↗

The CLU gene rs11136000 variant is significantly associated with Alzheimer's disease in Caucasian and Asian populations.Semantic proximity Read ↗

Alzheimer's risk variants in the clusterin gene are associated with alternative splicing.Semantic proximity Read ↗

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Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population.Semantic proximity Read ↗

Genetics of clusterin isoform expression and Alzheimer's disease risk.Semantic proximity Read ↗

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