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Invasive Glioblastoma Cells Acquire Stemness and Increased Akt Activation

1 Jun 2010

Abstract excerpt

Glioblastoma multiforme (GBM) is the most frequent and most aggressive brain tumor in adults. The dismal prognosis is due to postsurgery recurrences arising from escaped invasive tumor cells. The signaling pathways activated in invasive cells are under investigation, and models are currently designed in search for therapeutic targets. We developed here an in vivo model of human invasive GBM in mouse brain from a...

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PMID: 20563248
DOI: 10.1593/neo.10126

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