Article

Disrupting Akt-Wnt/β-catenin signaling suppresses glioblastoma stem cell growth and tumor progression in immunocompetent mice

2025-07-31

Abstract excerpt

Glioblastoma (GBM) is an aggressive primary malignant brain tumor in adults with limited therapeutic options and a median survival of 12-18 months post-diagnosis. The PI3K/Akt and Wnt/β-catenin signaling pathways promote GBM cell growth and survival, invasiveness and therapeutic resistance. We hypothesize that inhibiting Akt and β-catenin, which are key central regulatory components of the PI3K/Akt and Wnt/β-caten...

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Literature Corpus work: e73679dc-9c85-5e1c-8650-2a91f68ebfaa
DOI: 10.1101/2025.07.25.666376

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