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Article

Highly infiltrative brain tumours show reduced chemosensitivity associated with a stem cell-like phenotype.

Neuropathology and applied neurobiology - 1 Aug 2009

Johannessen T-C A, Wang J, Skaftnesmo K-O, Sakariassen P Ø, Enger P Ø, Petersen K, Øyan A M, Kalland K-H, Bjerkvig R, Tysnes B B

Abstract excerpt

AIMS: Cancer stem-like cells might have important functions in chemoresistance. We have developed a model where highly infiltrative brain tumours with a stem-like phenotype were established by orthotopic transplantation of human glioblastomas to immunodeficient rats. Serial passaging gradually tr...

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Identifiers

PMID: 19508445
DOI: 10.1111/j.1365-2990.2008.01008.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19508445-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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