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Article

Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells.

Neuro-oncology - 1 Feb 2012

Wakimoto Hiroaki, Mohapatra Gayatry, Kanai Ryuichi, Curry William T, Yip Stephen, Nitta Mai, Patel Anoop P, Barnard Zachary R, Stemmer-Rachamimov Anat O, Louis David N, Martuza Robert L, Rabkin Samuel D

Abstract excerpt

The clinicopathological heterogeneity of glioblastoma (GBM) and the various genetic and phenotypic subtypes in GBM stem cells (GSCs) are well described. However, the relationship between GSCs and the corresponding primary tumor from which they were isolated is poorly understood. We have established GSC-enriched neurosphere cultures from 15 newly diagnosed GBM specimens and examined the relationship between the...

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Identifiers

PMID: 22067563
DOI: 10.1093/neuonc/nor195
PMCID: PMC3266381

Genes

GSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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