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Combined PI3Kα-mTOR Targeting of Glioma Stem Cells

14 Dec 2020

Abstract excerpt

Glioblastoma (GBM) is the most common and lethal primary intrinsic tumour of the adult brain and evidence indicates disease progression is driven by glioma stem cells (GSCs). Extensive advances in the molecular characterization of GBM allowed classification into proneural, mesenchymal and classical subtypes, and have raised expectations these insights may predict response to targeted therapies. We utilized GBM...

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PMID: 33318517
DOI: 10.1038/s41598-020-78788-z

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