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Metabolism-based isolation of invasive glioblastoma cells with specific gene signatures and tumorigenic potential

1 Jan 2020

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) is a highly aggressive brain tumor with rapid subclonal diversification, harboring molecular abnormalities that vary temporospatially, a contributor to therapy resistance. Fluorescence-guided neurosurgical resection utilizes the administration of 5-aminolevulinic acid (5-ALA) generating individually fluorescent tumor cells within a background population of non-neoplastic cells in...

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PMID: 32904996
DOI: 10.1093/noajnl/vdaa087

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