Angiogenesis-independent tumor growth mediated by stem-like cancer cells.

doi:10.1073/pnas.0607668103

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Article

Angiogenesis-independent tumor growth mediated by stem-like cancer cells.

Proceedings of the National Academy of Sciences of the United States of America - 31 Oct 2006

Sakariassen Per Ø, Prestegarden Lars, Wang Jian, Skaftnesmo Kai-Ove, Mahesparan Rupavathana, Molthoff Carla, Sminia Peter, Sundlisaeter Eirik, Misra Anjan, Tysnes Berit Bølge, Chekenya Martha, Peters Hans, Lende Gabriel, Kalland Karl Henning, Øyan Anne M, Petersen Kjell, Jonassen Inge, van der Kogel Albert, Feuerstein Burt G, Terzis A Jorge A, Bjerkvig Rolf, Enger Per Øyvind

Abstract excerpt

In this work, highly infiltrative brain tumors with a stem-like phenotype were established by xenotransplantation of human brain tumors in immunodeficient nude rats. These tumors coopted the host vasculature and presented as an aggressive disease without signs of angiogenesis. The malignant cells expressed neural stem cell markers, showed a migratory behavior similar to normal human neural stem cells, and gave...

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Identifiers

PMID: 17056721
DOI: 10.1073/pnas.0607668103
PMCID: PMC1618812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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