Article
Proliferation and invasion: plasticity in tumor cells.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2005
Gao Chong-Feng, Xie Qian, Su Yan-Li, Koeman Julie, Khoo Sok Kean, Gustafson Margaret, Knudsen Beatrice S, Hay Rick, Shinomiya Nariyoshi, Vande Woude George F
Abstract excerpt
Invasive and proliferative phenotypes are fundamental components of malignant disease, yet basic questions persist about whether tumor cells can express both phenotypes simultaneously and, if so, what are their properties. Suitable in vitro models that allow characterization of cells that are purely invasive are limited because proliferation is required for cell maintenance. Here, we describe glioblastoma cells...
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