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Article

Gliosarcoma Stem Cells Undergo Glial and Mesenchymal Differentiation In Vivo

23 Nov 2009

Abstract excerpt

Cancer stem cells (CSCs) are characterized by their self-renewing potential and by their ability to differentiate and phenocopy the original tumor in orthotopic xenografts. Long-term propagation of glioblastoma (GBM) cells in serum-containing medium results in loss of the CSCs and outgrowth of cells genetically and biologically divergent from the parental tumors. In contrast, the use of a neurosphere assay, a...

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PMID: 19937755
DOI: 10.1002/stem.264

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