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Article

Catechol-O-methyl transferase and schizophrenia.

Psychiatria Danubina - 1 Jun 2010

Sagud Marina, Mück-Seler Dorotea, Mihaljević-Peles Alma, Vuksan-Cusa Bjanka, Zivković Maja, Jakovljević Miro, Pivac Nela

Abstract excerpt

Catechol-O-methyl transferase (COMT) is an enzyme involved in the degradation of dopamine. The most commonly examined polymorphism within the COMT gene is Val108/158Met polymorphism, which results in three to fourfold difference in COMT enzyme activity. It is particularely important in prefrontal cortex, since COMT activity is the most important regulator of the prefrontal dopamine function. Given the association...

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Source

Identifiers

PMID: 20562760

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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