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Article

Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: new data and meta-analysis.

Journal of psychiatric research - 1 Jan 2011

Costas Javier, Sanjuán Julio, Ramos-Ríos Ramón, Paz Eduardo, Agra Santiago, Ivorra José Luis, Páramo Mario, Brenlla Julio, Arrojo Manuel

Abstract excerpt

Catechol-O-methyltransferase (COMT) has been largely studied in relation to schizophrenia susceptibility. Most studies focused on the functional single nucleotide polymorphism (SNP) rs4680 that causes a substitution of Val by Met at codon 158 of the COMT protein. Recent meta-analyses do not support an association between allelic variants at rs4680 and schizophrenia. However, the putative role of overdominance has...

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Identifiers

PMID: 20488458
DOI: 10.1016/j.jpsychires.2010.04.021

Genes

COMT

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Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: new data and meta-analysis.PMID 20488458Read ↗

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