Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Catechol-O-methyltransferase gene Val108/158Met polymorphism, and susceptibility to schizophrenia: association is more significant in women.

Brain research. Molecular brain research - 6 Dec 2004

Sazci Ali, Ergul Emel, Kucukali Ismail, Kilic Gamze, Kaya Guner, Kara Ihsan

Abstract excerpt

Schizophrenia is a complex disorder with a polygenic inheritance. Catechol-O-methyltransferase (COMT) plays a significant role in the regulation of dopaminergic systems. A polymorphism at COMT Val108/158Met has been identified in association with schizophrenia. We examined the allele and genotype association of the COMT Val108/158Met polymorphism of 297 unrelated schizophrenic patients who strictly met DSM-IV...

Topics

Join the communities discussing this publication.

Amino Acid Substitution
Catechol O-Methyltransferase
Genetic Testing
Methionine
Schizophrenia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15548428
DOI: 10.1016/j.molbrainres.2004.09.005

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Catechol-O-methyltransferase gene Val108/158Met polymorphism, and susceptibility to schizophrenia: association is more significant in women.PMID 15548428Read ↗

The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects.Semantic proximity Read ↗

Catechol-O-methyl transferase and schizophrenia.Semantic proximity Read ↗

Genetic association of catechol-O-methyltransferase val(158)met polymorphism in Saudi schizophrenia patients.Semantic proximity Read ↗

Association between Val108/158 Met polymorphism of the COMT gene and schizophrenia.Semantic proximity Read ↗

Gender-specific COMT Val158Met polymorphism association in Spanish schizophrenic patients.Semantic proximity Read ↗

Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics.Semantic proximity Read ↗

Sex-dependent effect on the association of COMT Val158Met polymorphism with schizophrenia clinical symptoms and cognitive impairmentSemantic proximity Read ↗

Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis.Semantic proximity Read ↗

Association of the functional polymorphism in the catechol-O-methyltransferase gene with schizophrenia in the three ethnic groups of the Malaysian population.Semantic proximity Read ↗

Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.Semantic proximity Read ↗

Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies.Semantic proximity Read ↗

Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.