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Article

[COMT Val158Met polymorphism and schizophrenia in a series of Spanish patients].

Medicina clinica - 20 Jan 2007

Díez-Martín Justo, Hoenicka Janet, Martínez Isabel, Aragüés María, Rodríguez-Jiménez Roberto, Jiménez-Arriero Miguel Angel, Ponce Guillermo, Rubio Gabriel, Palomo Tomás

Abstract excerpt

BACKGROUND AND OBJECTIVE: Catecol-O-methyl transferase (COMT) enzyme plays a significant role in the regulation of the dopaminergic system in the prefrontal cortex. Several studies have assessed the association between modifications of the COMT activity and schizophrenia, but without consistent results. COMT gene contains a single nucleotide functional polymorphism which produces the change of a valine for a...

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Share to Catechol O-Methyltransferase
Share to Chromosomes, Human, Pair 22

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 17266899
DOI: 10.1157/13097467

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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[COMT Val158Met polymorphism and schizophrenia in a series of Spanish patients].PMID 17266899Read ↗

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Association between Val108/158 Met polymorphism of the COMT gene and schizophrenia.Semantic proximity Read ↗

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