Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection.

doi:10.1016/j.ajhg.2010.05.004

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Article

Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection.

American journal of human genetics - 11 Jun 2010

Zhernakova Alexandra, Elbers Clara C, Ferwerda Bart, Romanos Jihane, Trynka Gosia, Dubois Patrick C, de Kovel Carolien G F, Franke Lude, Oosting Marije, Barisani Donatella, Bardella Maria Teresa, Joosten Leo A B, Saavalainen Paivi, van Heel David A, Catassi Carlo, Netea Mihai G, Wijmenga Cisca

Abstract excerpt

Celiac disease (CD) is an intolerance to dietary proteins of wheat, barley, and rye. CD may have substantial morbidity, yet it is quite common with a prevalence of 1%-2% in Western populations. It is not clear why the CD phenotype is so prevalent despite its negative effects on human health, especially because appropriate treatment in the form of a gluten-free diet has only been available since the 1950s, when...

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PMID: 20560212
DOI: 10.1016/j.ajhg.2010.05.004
PMCID: PMC3032060

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NOD2

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