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Article

Celiac disease susceptibility: The genome and beyond.

International review of cell and molecular biology - 1 Jan 2021

García-Santisteban Iraia, Romero-Garmendia Irati, Cilleros-Portet Ariadna, Bilbao Jose Ramon, Fernandez-Jimenez Nora

Abstract excerpt

Celiac Disease (CeD) is an immune-mediated complex disease that is triggered by the ingestion of gluten and develops in genetically susceptible individuals. It has been known for a long time that the Human Leucocyte Antigen (HLA) molecules DQ2 and DQ8 are necessary, although not sufficient, for the disease development, and therefore other susceptibility genes and (epi)genetic events must participate in CeD...

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PMID: 33707051
DOI: 10.1016/bs.ircmb.2020.10.002

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