Article
Newly identified genetic risk variants for celiac disease related to the immune response.
Nature genetics - 1 Apr 2008
Hunt Karen A, Zhernakova Alexandra, Turner Graham, Heap Graham A R, Franke Lude, Bruinenberg Marcel, Romanos Jihane, Dinesen Lotte C, Ryan Anthony W, Panesar Davinder, Gwilliam Rhian, Takeuchi Fumihiko, McLaren William M, Holmes Geoffrey K T, Howdle Peter D, Walters Julian R F, Sanders David S, Playford Raymond J, Trynka Gosia, Mulder Chris J J, Mearin M Luisa, Verbeek Wieke H M, Trimble Valerie, Stevens Fiona M, O'Morain Colm, Kennedy Nicholas P, Kelleher Dermot, Pennington Daniel J, Strachan David P, McArdle Wendy L, Mein Charles A, Wapenaar Martin C, Deloukas Panos, McGinnis Ralph, McManus Ross, Wijmenga Cisca, van Heel David A
Abstract excerpt
Our genome-wide association study of celiac disease previously identified risk variants in the IL2-IL21 region. To identify additional risk variants, we genotyped 1,020 of the most strongly associated non-HLA markers in an additional 1,643 cases and 3,406 controls. Through joint analysis including the genome-wide association study data (767 cases, 1,422 controls), we identified seven previously unknown risk...
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