Article
A common CTLA4 haplotype associated with coeliac disease.
European journal of human genetics : EJHG - 1 Apr 2005
Hunt Karen A, McGovern Dermot P B, Kumar Parveen J, Ghosh Subrata, Travis Simon P L, Walters Julian R F, Jewell Derek P, Playford Raymond J, van Heel David A
Abstract excerpt
Coeliac disease is a common enteropathy with a strong inherited risk characterised by dietary wheat, rye and barley induced T-cell activation. Although there is replicated linkage to 2q33, results are inconsistent from association studies of the most promising candidate genes: the CD28/CTLA4/ICOS cluster. CTLA4 plays a key role in regulating T lymphocyte mediated inflammatory responses, and variants in the 3'...
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