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Article

Crohn's disease risk alleles on the NOD2 locus have been maintained by natural selection on standing variation.

Molecular biology and evolution - 1 Jun 2012

Nakagome Shigeki, Mano Shuhei, Kozlowski Lukasz, Bujnicki Janusz M, Shibata Hiroki, Fukumaki Yasuaki, Kidd Judith R, Kidd Kenneth K, Kawamura Shoji, Oota Hiroki

Abstract excerpt

Risk alleles for complex diseases are widely spread throughout human populations. However, little is known about the geographic distribution and frequencies of risk alleles, which may contribute to differences in disease susceptibility and prevalence among populations. Here, we focus on Crohn's disease (CD) as a model for the evolutionary study of complex disease alleles. Recent genome-wide association studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22319155
DOI: 10.1093/molbev/mss006
PMCID: PMC3697811

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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