Article
Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease.
Gastroenterology - 1 Sept 2009
Romanos Jihane, van Diemen Cleo C, Nolte Ilja M, Trynka Gosia, Zhernakova Alexandra, Fu Jingyuan, Bardella Maria Teresa, Barisani Donatella, McManus Ross, van Heel David A, Wijmenga Cisca
Abstract excerpt
BACKGROUND & AIMS: Celiac disease (CD) is a common chronic disorder of the small intestine, resulting from aberrant cellular responses to gluten peptides, and often remains undiagnosed. It is a complex genetic disorder, although 95% of the patients carry the risk heterodimer human leukocyte antigen (HLA)-DQ2. Genome-wide association studies on CD have identified 9 non-HLA loci that also contribute to CD risk,...
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