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Article

Identification and Characterization of Bmi-1-responding Element within the Human p16 Promoter*

16 Jun 2010

Abstract excerpt

Bmi-1, the first functionally identified polycomb gene family member, plays critical roles in cell cycle regulation, cell immortalization, and cell senescence. Bmi-1 is involved in the development and progression of carcinomas and is a potent target for cancer therapy. One important pathway regulated by Bmi-1 is that involving two cyclin-dependent kinase inhibitors, p16(Ink4a) and p19(Arf), as Bmi-1 represses the...

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Identifiers

PMID: 20551323
DOI: 10.1074/jbc.m110.133686

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