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Article

Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16 <sup>INK4a</sup>

28 Feb 2006

Abstract excerpt

Increased mitogenic signaling by positive effectors such as Ras or Myc can trigger senescence in normal cells, a response believed to function as a tumor-suppressive mechanism. We report here the existence of a checkpoint that monitors hypoproliferative signaling imbalances. Normal human fibroblasts with one copy of the c-myc gene inactivated by targeted homologous recombination switched with an increased...

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PMID: 16537449
DOI: 10.1073/pnas.0600069103

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