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Article

BMI-1 Promotes Ewing Sarcoma Tumorigenicity Independent of <i>CDKN2A</i> Repression

12 Aug 2008

Abstract excerpt

Deregulation of the polycomb group gene BMI-1 is implicated in the pathogenesis of many human cancers. In this study, we have investigated if the Ewing sarcoma family of tumors (ESFT) expresses BMI-1 and whether it functions as an oncogene in this highly aggressive group of bone and soft tissue tumors. Our data show that BMI-1 is highly expressed by ESFT cells and that, although it does not significantly affect...

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PMID: 18701473
DOI: 10.1158/0008-5472.can-07-6152

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