Article
Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults.
The Journal of allergy and clinical immunology - 1 Jul 2010
Mukhopadhyay Somnath, Sypek Joseph, Tavendale Roger, Gartner Ulrike, Winter John, Li Wei, Page Karen, Fleming Margaret, Brady Jeff, O'Toole Margot, Macgregor Donald F, Goldman Samuel, Tam Steve, Abraham William, Williams Cara, Miller Douglas K, Palmer Colin N A
Abstract excerpt
BACKGROUND: Matrix metalloproteinase (MMP)-12-mediated pathologic degradation of the extracellular matrix and the subsequent repair cycles influence the airway changes in patients with asthma and chronic obstructive pulmonary disease (COPD). The common serine variant at codon 357 of the MMP12 gene (rs652438) is associated with clinical manifestations consistent with more aggressive matrix degradation in other...
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