MMP12, lung function, and COPD in high-risk populations.

doi:10.1056/NEJMoa0904006

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Article

MMP12, lung function, and COPD in high-risk populations.

The New England journal of medicine - 31 Dec 2009

Hunninghake Gary M, Cho Michael H, Tesfaigzi Yohannes, Soto-Quiros Manuel E, Avila Lydiana, Lasky-Su Jessica, Stidley Chris, Melén Erik, Söderhäll Cilla, Hallberg Jenny, Kull Inger, Kere Juha, Svartengren Magnus, Pershagen Göran, Wickman Magnus, Lange Christoph, Demeo Dawn L, Hersh Craig P, Klanderman Barbara J, Raby Benjamin A, Sparrow David, Shapiro Steven D, Silverman Edwin K, Litonjua Augusto A, Weiss Scott T, Celedón Juan C

Abstract excerpt

BACKGROUND: Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups. METHODS: We tested for an association between single-nucleotide polymorphisms (SNPs) in the gene encoding matrix metalloproteinase 12 (MMP12) and a measure of lung function (prebronchodilator forced expiratory volume...

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Identifiers

PMID: 20018959
DOI: 10.1056/NEJMoa0904006
PMCID: PMC2904064

Genes

MMP12
FEV

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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