Article
Limited intra-individual variability in hypoxanthine-Guanine phosphoribosyl transferase, thiopurine S-methyl transferase, and xanthine oxidase activity in inflammatory bowel disease patients during 6-thioguanine therapy.
Nucleosides, nucleotides & nucleic acids - 1 Jun 2010
van Asseldonk D P, de Boer N K H, Smid K, Mulder C J, van Bodegraven A A, Peters G J
Abstract excerpt
6-Thioguanine (6-TG) may be indicated in case of intolerance of or resistance to conventional thiopurines in the treatment of inflammatory bowel diseases (IBD). The aim of our study was to evaluate the intrapatient variability in the 6-TG metabolizing enzymes: hypoxanthine-guanine phosphoribosyl...
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