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Article

Deletion of glutathione-s-transferase m1 reduces azathioprine metabolite concentrations in young patients with inflammatory bowel disease.

Journal of clinical gastroenterology - 1 Jan 2014

Stocco Gabriele, Cuzzoni Eva, De Iudicibus Sara, Franca Raffaella, Favretto Diego, Malusà Noelia, Londero Margherita, Cont Gabriele, Bartoli Fiora, Martelossi Stefano, Ventura Alessandro, Decorti Giuliana

Abstract excerpt

GOALS: To investigate, in young patients with inflammatory bowel disease (IBD) treated with azathioprine, the association between genetic polymorphisms of thiopurine-S-methyl-transferase (TPMT), inosine-triphosphate-pyrophosphatase (ITPA), and glutathione-S-transferases (GST), involved in azathioprine metabolism, the concentration of the main metabolites of azathioprine, thioguanine nucleotides (TGNs) and the...

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Share to Azathioprine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23787247
DOI: 10.1097/MCG.0b013e31828b2866

Genes

ITPA
TPMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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