Article
On therapeutic drug monitoring of thiopurines in inflammatory bowel disease; pharmacology, pharmacogenomics, drug intolerance and clinical relevance.
Current drug metabolism - 1 Nov 2009
Van Asseldonk Dirk P, de Boer Nanne K H, Peters Godefridus J, Veldkamp Agnes I, Mulder Chris J, Van Bodegraven Ad A
Abstract excerpt
Thiopurines such as azathioprine, 6-mercaptopurine and 6-thioguanine are antimetabolites that have been used for several decades in the treatment of several diseases including inflammatory bowel diseases. Additional anti-inflammatory properties of these thiopurines have been discovered in recent years. Thiopurine metabolism is complex due to the involvement of multiple enzymes, of which the activities are...
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