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Article

Monitoring of long-term thiopurine therapy among adults with inflammatory bowel disease.

Scandinavian journal of gastroenterology - 1 Nov 2004

Hindorf U, Lyrenäs E, Nilsson A, Schmiegelow K

Abstract excerpt

BACKGROUND: The immunosuppressive effects of thiopurine drugs are mainly mediated through their intracellular metabolism into active 6-thioguanine nucleotide (6-TGN) metabolites, which are incorporated into DNA. Erythrocyte 6-TGN (E-6TGN) levels have been proposed as an instrument for monitoring treatment. The aim of the study was to use erythrocyte E-6TGN, methylated mercaptopurine (MeMP) metabolites, and...

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PMID: 15545169
DOI: 10.1080/00365520410007980

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TPMT

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