Article
Population pharmacokinetics of azathioprine active metabolite in patients with inflammatory bowel disease and dosage regimens optimisation.
Basic & clinical pharmacology & toxicology - 1 Mar 2021
Lin Rongfang, Lin Weiwei, Wang Changlian, Dong Jiashan, Zheng Weiwei, Zeng Dayong, Liu Yiwei, Lin Cuihong, Jiao Zheng, Huang Pinfang
Abstract excerpt
Azathioprine is a first-line drug used to maintain the remission of inflammatory bowel disease (IBD). As a prodrug, azathioprine is metabolised to produce active 6-thioguanine nucleotides (6-TGN). There are large individual variations in the pharmacokinetics/pharmacodynamics of 6-TGN in patients with IBD. Here, we aimed to develop a model to quantitatively investigate factors that affect 6-TGN pharmacokinetics to...
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