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Article

Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease: effect of N-acetyl transferase polymorphisms.

World journal of gastroenterology - 28 Mar 2015

Stocco Gabriele, Cuzzoni Eva, De Iudicibus Sara, Favretto Diego, Malusà Noelia, Martelossi Stefano, Pozzi Elena, Lionetti Paolo, Ventura Alessandro, Decorti Giuliana

Abstract excerpt

AIM: To evaluate variation of the concentration of thiopurine metabolites after 5-aminosalicylate (5-ASA) interruption and the role of genetic polymorphisms of N-acetyl transferase (NAT) 1 and 2. METHODS: Concentrations of thioguanine nucleotides (TGN) and methymercaptopurine nucleotides (MMPN), metabolites of thiopurines, were measured by high performance liquid chromatography in 12 young patients (3 females and...

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Identifiers

PMID: 25834322
DOI: 10.3748/wjg.v21.i12.3571
PMCID: PMC4375579

Genes

NAT1
NAT2
ITPA
TPMT

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