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Article

Limitation to the use of the urinary S-/R-mephenytoin ratio in pharmacogenetic studies.

British journal of clinical pharmacology - 1 Mar 1991

Zhang Y, Blouin R A, McNamara P J, Steinmetz J, Wedlund P J

Abstract excerpt

The reproducibility of the S-/R-mephenytoin ratio was examined in urines stored at -20 degrees C over 2 years. Large changes in this ratio were observed in some urine samples stored for only a few months under these conditions. The changes observed in the S-/R-mephenytoin ratio are attributed to the decomposition of an acid labile metabolite of S-mephenytoin which is eliminated in the urine. The instability of...

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Identifiers

PMID: 2054275
DOI: 10.1111/j.1365-2125.1991.tb05542.x
PMCID: PMC1368365

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Source receipt: pubmed, retrieved 7 Sept 2026.

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