Article
Re-evaluation of the metabolism of carbocisteine in a British white population.
Pharmacogenetics - 1 Oct 1993
Gregory W L, James O F, Turner I, Meese C O, Idle J R
Abstract excerpt
It has been claimed that the amino acid derivative carbocisteine is predominantly metabolized by sulfoxidation and that this pathway exhibits a genetic polymorphism. Moreover, those subjects with a 'poor metabolizer' phenotype have been thought to have a genetic predisposition to developing certain diseases. We have confirmed the observations of others that this marker drug does not undergo significant...
Topics
- Adult
- Aged
- Aged, 80 and over
- Biotransformation
- Carbocysteine
- Female
- Humans
- Male
- Middle Aged
- Phenotype
- Polymorphism, Genetic
- United Kingdom
- White People
