Article
Reproducibility over time of mephenytoin and debrisoquine hydroxylation phenotypes.
Pharmacology & toxicology - 1 Jul 1993
Llerena A, Valdivielso M J, Benítez J, Bertilsson L
Abstract excerpt
Mephenytoin and debrisoquine hydroxylation phenotypes were determined twice in 15 Spanish healthy volunteers with an interval of about one year. The phenotype assignment did not change in any subject for either debrisoquine or mephenytoin. Among extensive metabolisers of mephenytoin, there was a...
Topics
- Adult
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Female
- Humans
- Hydroxylation
- Male
- Mephenytoin
- Mixed Function Oxygenases
- Phenotype
- Reproducibility of Results
- Stereoisomerism
- Time Factors