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Article

Mephenytoin as a probe for CYP2C19 phenotyping:effect of sample storage, intra-individual reproducibility and occurrence of adverse events.

British journal of clinical pharmacology - 1 May 2001

Tamminga W J, Wemer J, Oosterhuis B, Wieling J, Touw D J, de Zeeuw R A, de Leij L F, Jonkman J H

Abstract excerpt

AIMS: To further evaluate mephenytoin as a probe for CYP2C19 phenotyping. METHODS: Healthy subjects (n = 2638) were phenotyped using the urinary (S)-mephenytoin to (R)-mephenytoin ratio. This method was evaluated for (a) the stability of the S/R-ratio following sample storage, (b) the intraindividual reproducibility of the ratio, and (c) the occurrence of adverse events. RESULTS: After prolonged storage, the...

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Identifiers

PMID: 11422005
DOI: 10.1046/j.1365-2125.2001.01331.x
PMCID: PMC2014478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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