Article
Mephenytoin phenotyping: lack of haematologic effect and timing of urine collections.
Pharmacogenetics - 1 Oct 1991
Relling M V, Ayers D, Heideman R L
Abstract excerpt
Mephenytoin is the prototype substrate for the genetically regulated, polymorphically distributed cytochrome P450, mephenytoin hydroxylase. Mephenytoin is an anticonvulsant which has been associated with leukopenia when used chronically. The haematologic effects of a single dose of oral mephenytoin, as is typically used to determine drug metabolism phenotype for this polymorphism, have not been reported. We...
Topics
- Adult
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme System
- Hematocrit
- Humans
- Leukocyte Count
- Male
- Mephenytoin
- Mixed Function Oxygenases
- Phenotype